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VUF11207 fumarate
CAS No. 1785665-61-3
VUF11207 fumarate( —— )
Catalog No. M23800 CAS No. 1785665-61-3
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 125 | In Stock |
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| 25MG | 258 | In Stock |
|
| 50MG | 447 | In Stock |
|
| 100MG | 644 | In Stock |
|
| 200MG | 896 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVUF11207 fumarate
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NoteResearch use only, not for human use.
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Brief DescriptionVUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
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DescriptionVUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
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In VitroCell Viability Assay Cell Line:Osteoclast precursor cells (RANKL? and TnF?α?induced) Concentration:0.17 nM (100 ng/mL)Incubation Time:5 days Result:Showed inhibitory effect on CXCL12.
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In VivoAnimal Model:Male c57Bl/6J wild?type/WT mice (8?10?week?old; 20?25 g; LPS-induced)Dosage:100 μg/day Administration:Subcutaneous injection; single daily for 5 days Result:Significantly decreased the number of osteoclasts and suppressed Cathepsin K mRNA, ranKl and TnF?α mRNA expression levels.Reduced the area of LPS-induced bone resorption.
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Synonyms——
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PathwayAutophagy
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TargetCXCR
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RecptorCXCR7
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Research Area——
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Indication——
Chemical Information
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CAS Number1785665-61-3
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Formula Weight586.65
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Molecular FormulaC31H39FN2O8
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Purity>98% (HPLC)
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SolubilityDMSO:247 mg/mL (421.03 mM; Need ultrasonic)
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SMILESC/C(CN(CCC1N(C)CCC1)C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=C\C3=C(F)C=CC=C3.OC(/C=C/C(O)=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wijtmans M, et al. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur J Med Chem. 2012 May;51:184-92.
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